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Basic experiments on safety evaluation of 0.3%, 1% and 3% solution of KW-1062 (DE-020 eye drops) were carried out. These eye drops applied topically to rabbits eyes had no undesirable local or systemic effects as follows: 1. Repeated instillations of DE-020 eye drops (One drop every 1 hr for 4 hrs) showed no significant irritation except only a temporary and slight congestion localized at the conjunctivae. 2. Daily instillation of DE-020 eye drops (3 times daily for 28 days) showed no abnormal findings in the eye mucosa, clinical signs, body weight, hematological examination, biochemical examination, autopsy, organ weight and histopathological examination.

SAFETY EVALUATION OF DE-020 EYE DROPS : Eye irritation test and subacute toxicity test in rabbits