English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Drug interactions can be divided into those involving the pharmacokinetics of a drug and those affecting the pharmacodynamic response to it. Following strategies should be considered for avoiding pharmacokinetic drug interactions of new chemical entities under development. 1. To estimate the major metabolic pathways (including metabolic activation) using human liver preparations. 2. To identify the enzyme systems participating in the major metabolic pathways. 3. To examine metabolic inhibition for other drugs and by other drugs. 4. To confirm a pharmacokinetic effect for the combined drugs in vivo.

A proposal for avoiding toxic interactions of a drug under development to estimate inhibitory ability on the drug metabolizing enzymes in human liver.