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Antibodies, such as anti-Rh18 (Hr/Hr S ), that react with the common products of  RHCE  can cause HDN as well as severe hemolytic transfusion reactions. Individuals with anti-Rh18 antibodies can have different  RHCE  genetic backgrounds; therefore, sera and RBCs from these individuals may cross-react. In these situations, genotyping may be the best method to determine compatibility. We report a 26-year-old pregnant Puerto Rican woman who presented at 31 weeks’ gestation with anti-E and anti-Rh18 in her serum. No potential donors were identified among family members or within the American Rare Donor Program; therefore, a unit of the patient’s RBCs was collected one week before her planned caesarian section. To improve our ability to supply blood for this patient in the future, molecular testing was performed. The patient was found to be homozygous for an RH haplotype in which a variant  RHD*DAR , is linked to a variant  RHCE*ceAR . The  DAR-ceAR  haplotype has been described in Dutch-African populations, but this is the first report of an individual self-identified of Hispanic ethnicity. This case report demonstrates the clinical importance of molecular testing of patients with rare Rh phenotypes.  Immunohematology 2006;22:132–135.

Serologic and molecular genetic management of a pregnancy complicated by anti-Rh18