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White matter hyperintensities (WMH) are lesions in the brain that show up as areas of increased brightness when visualised by T2-weighted or fluidattenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI). WMH commonly form in normal aging, increasing in prevalence from 11-21 percent at 64 years of age to 94 percent at 82 years of age.1,2 They are more common in those with small vessel disease and cardiovascular risk factors, and they display heritability of up to 76 percent.3

WHITE MATTER HYPERINTENSITIES IN ASTRONAUTS: POSSIBLE IMPLICATIONS FOR FUTURE SPACE OPERATIONS