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It has been reported that there are various metabolic abnormalities, obesity and type-2 DM associated with NAFLD in western world but there are very few study on metabolic parameters and insulin resistance associated with NAFLD in India. So this study was designed with an aim to determine the presence of component of metabolic syndrome and insulin resistance in non alcoholic fatty liver disease. Material and methods: 150 patients were included in this study based on inclusion and exclusion criteria. Detail history of the patients were noted that includes drug history, patients were examined for evidence of clinical manifestation of chronic liver disease body mass index and all other metabolic parameters of all patients were measured. Result: The mean of fasting insulin concentration was 9.156±1.6 uIU/ml in group A and5.94±1.364 uIU/ml in group B. The P value was 0.0026. The mean value of HOMA-IR was 2.18±0.26 in group A and 1.3836 ±0.44 in group B. This difference is statically significant as P value is 0.0001. Conclusion: To conclude most of the patient with NAFLD were obese but some having normal body weight also. Patients with NAFLD have higher FPG, dyslipidemia, fasting insulin concentration and HOMA-IR even though they are not diabetic. So insulin resistance, obesity, lipotoxicity and environmental factor are of major concern in development of non alcoholic fatty liver disease. Keyword: NAFLD, Insulin Resistance, Dyslipidemia Original research article Satyanarayana, et al. Metabolic Parameter and Insulin Resistance in Non Alcoholic Fatty Liver Disease D185 International Journal of Contemporary Medical Research International Journal of Contemporary Medicine Surgery and Radiology Volume 4 | Issue 4 | October-December 2019 ISSN (Online): 2565-4810; (Print): 2565-4802 | ICV 2018: 86.41 | Exclusion criteria Inclusion criteria Age more than 35 years Diabetes mellitus Both sex Any disease of liver infective or autoimmune NAFLD diagnosed by USG Steatogenic drug, Alcoholic Sample size: Based on prevalence of NAFLD and confidence interval of 95%, sample size was calculated to 149, so 150 patients were included for this study.9 Ethics: Before start of the study permission of institutional ethics committee was obtained. Informed consent was obtained from all patients enrolled in this study. Methods: 150 patients were included in this study based on inclusion and exclusion criteria. Detail history of the patients were noted that includes drug history, patients were examined for evidence of clinical manifestation of chronic liver disease body mass index of all patients were measured waist circumference was calculated. Various biochemical parameters like fasting plasma glucose and post prandial plasma glucose was measured by glucose oxidise peroxidise method.For total cholesterol, we used Liebermann-Burchard reaction colorimetric method; triglyceride was estimated by method of Neri and Fringe. HDL concentration was estimated by precipitation method. LDL concentration was calculated by WHO formula, LDLcholesterol= total cholesterol– TG/5 – HDL (mg/dL). Plasma insulin was determined by using enzyme-linked immunosorbent assay. HOMA-IR was calculated by using this formula (FPI X FPG)/22.5.10 Value more than 1.64 was considered insulin resistance. Study designs: Patients selected as per exclusion and inclusion criteria were kept in Group A, in Group B 150 apparently healthy patients without NAFLD and diabetes mellitus were taken as control. STATISTICAL ANALYSIS Data was collected on Microsoft excel sheet and analysis was done by using mean, proportion chi square test and unpaired t-test was used, P-value less than 0.05 was taken significant.

Metabolic Parameter and Insulin Resistance in Non Alcoholic Fatty Liver Disease Patient Attending Tertiary Care Hospital Coastal Andhra Pradesh