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Several epidemiologic studies have shown elevated uric acid levels to predict increased risk of cardiovascular events. Few studies have addressed the value of this biomarker across the whole spectrum of patients with ACS (Acute Coronary Syndrome) especially in Indian settings. Thus, the aim of this study was investigate whether there is an association between serum uric acid level with CAD (Coronary Artery Disease) risk factors its and severity in ACS patients. Material and methods: This cross -sectional study included 100 consecutive patients admitted with acute coronary syndrome in the cardiology and medicine department of the institution. The presence and severity of CAD was determined by the following clinical vessel score; Absent: no coronary lesions, 1 vessel, 2 vessel and 3 vessel disease based on the number of coronary arteries involved. The correlation of serum uric acid levels with CAD risk factors and the severity of CAD in the ACS patients was analysed statistically. Results: There was a significant association between uric acid and the coronary angiographic findings (P<0.001). The patients in the hyperuricemia group had more number of coronary vessels involved than the other group. Conclusion: The serum uric acid level is correlated with the presence and severity of CAD by coronary angiographic findings (P<0.001) in the acute coronary syndrome patients. Uric acid being an inexpensive and easily available biochemical marker, it will be of much use in settings with limited resources. Serum uric acid may be used to predict the severity of CAD.

The Co Relation of Serum Uric Acid with Risk Factors and Severity of Coronary Artery Disease (CAD) in Acute Coronary Syndrome