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The diagnosis and grading of fatty liver on ultrasonography has been frequently observed these days. The objective of the study was to detect different grades of NAFLD on ultrasonography and correlate it with serum lipid abnormalities. Material and Methods: This was an observational study on 384 patients referred to Bharati medical college and hospital during June 2018 to May 2019. Patients underwent ultrasonography and were considered “cases” if they had fatty liver. Correlation between NAFLD and serum lipid profile was done. Results: Of 384 patients, 352 (91.7%), 30 (7.8%) and 2 (0.5%) had grade I, II and III fatty liver respectively. Increased total cholesterol, serum triglycerides, LDL and VLDL were seen in 35.2%, 56.8%, 34.9% and 58.9% of cases respectively; while reduced HDL cholesterol levels in 56.5%. Total cholesterol to HDL and LDL to HDL ratio was raised in 37% and 21.1% of cases respectively. The distribution of mean total cholesterol, triglyceride, LDL levels, total cholesterol to HDL ratio and LDL to HDL ratio differed significantly in our study across three grades of NAFLD. The distribution of abnormality of different components of lipid profile did not differ significantly across fatty liver grades. Conclusion: Significant positive correlation was noted between NAFLD and increasing levels of serum total cholesterol, triglyceride, LDL, total cholesterol to HDL and LDL to HDL ratios. Significant positive correlation between the fatty liver grades and levels of different components of lipid profile was absent. We can thus conclude that dyslipidemia can be predicted in USG diagnosed NAFLD. Keyword: NAFLD, Dyslipidemia, USG, Grading, LDL, Triglycerides. Original research article Navale, et al. Grading of Non-Alcoholic Fatty Liver Disease on Ultrasound C188 International Journal of Contemporary Medical Research International Journal of Contemporary Medicine Surgery and Radiology Volume 4 | Issue 3 | July-September 2019 ISSN (Online): 2565-4810; (Print): 2565-4802 | ICV 2018: 86.41 | liver on USG of the age more than 18 years were included in the study. While the patients with history of regular alcohol intake more than 30 g/d in males and more than 20 g/d in females were excluded. Grading of fatty liver was done as – When the echogenicity was only marginally increased, it was grade I; when the echogenic liver obscured the echogenic walls of portal vein branches, it was grade II, and when the echogenic liver obscured the diaphragmatic outline, it was grade III fatty infiltration6. All the subjects in the study diagnosed as NAFLD on ultrasonography were investigated for serum lipid profile –total cholesterol (N< 200 mg/dl), HDL (N> 40 mg/ dl for males, >50 for females), triglycerides (N< 150mg/ dl), LDL (N< 100mg/dl), VLDL (N< 12-30mg/dl) total cholesterol: HDL ratio (N< 5 for male, < 4.5 for females) and LDL: HDL ratio (N< 3.6 for male, < 3.2 for females). Values outside this range were considered abnormal. Then, a correlation between NAFLD and serum lipid profile was done.

Grading of Non-Alcoholic Fatty Liver Disease on Ultrasound and Its Correlation with Lipid Profile