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Association between Chronic kidney disease (CKD) and increased risk of cardiovascular disease (CVD) is well established. Relationships of carotid intima-media thickness (CIMT) as a measure of subclinical atherosclerosis in CKD patients is a matter of debate. Current research aimed to study the role of CIMT in CKD patients and its association with the CKD staging. Material and Methods: Hundred CKD patients were studied and compared with 50 subjects without CKD in the Department of Medicine, G.R. Medical College & J.A. Group of Hospitals, Gwalior (M.P.) India. GFR was determined by MDRD (Modification of diet in renal study) equation. Study populations were subjected for high resolution B mode Carotid ultrasonography. Results: In case group, majority were males (68%) having age between 30-60 years (62%). Majority had stage V CKD (67%), 21% had stage III and 14% had stage IV CKD. Majority of the cases had CIMT between 0.9-1.0 mm (42%) followed by 0.7-0.8 mm (17%) as compared to 0.5-0.6 mm (42%) in control. Mean CIMT was significantly higher in cases (0.87±0.24) as compared to control (0.61±0.34) group (p<0.001). No significant difference in mean CIMT was found between different stages of CKD (p=0.649). Conclusion: CKD patients have significantly more carotid arterial wall thickness in comparison to age matched controls. The CIMT does not differ in different stages of CKD.

Carotid Intimal Medial Thickness (CIMT) in Patients of Chronic Kidney Disease (CKD) and its Association with CKD Staging