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The commonest day to day ailment of human beings is the gastrointestinal diseases. Apart from traditional uses, there are several reports on important pharmacological actions of musa sapientum. Study aimed to compare acid secretion and ulcer healing effect of methanolic extract of banana, ranitidine, and omeprazole. Material and methods: The present study was carried out on 30 albino rats for a period of 7 days. The animals were divided randomly into 5 groups of 6 animals each. Group I or control group received 3% gum acacia suspension orally for 7 days. Group II, III, IV and V received 100mg/kg of aspirin orally as a single dose the 7th day. Group III was pretreated with 100mg/ kg of MSE orally for 7 days. Group IV was pretreated with 20 mg/kg omeprazole and Group V was pretreated with 150mg/ kg of ranitidine orally for 7 days. After the administration of the drugs on the 7th Day, the albino rats were fasted for 24 hrs and then sacrificed after 4 hrs of pyloric ligation. Results: In the control group (n=6) the values of ulcer index (μmol tyrosin/ml), free acidity (mEq/l), total acidity (mEq/l), and volume of gastric juice (ml/4 hrs) were 0.22±0.01, 53.25±2.59, 72.24±4.19 and 5.1±0.32 respectively. When compared to aspirin treated group, the MSE pretreated group (100 mg/kg) single dose orally on 7th day showed significant reduction (p<0.01, n=6) of ulcer index, free and total acidity (mEq/l), and volume of gastric juice (ml/4 hrs), whose values were 5.3±0.46, 71.31±4.15, 72.24±4.19 and 65.4±2.9 respectively. Conclusion: The present study suggests that the methanolic extract of musa sapientum possesses significant ulceroprotective effect, which is comparable to omeprazole and ranitidine, except for gastric juice, where the effect of omeprazole was more. The observations of the present study puts forward omeprazole as a promising ulceroprotective agent, but further studies with more refined extracts and techniques on animal and human subjects are required to establish the true potential in terms of therapeutic and economic viability of this herbal plant.

Comparative Study of Methanolic Extract of Banana, Ranitidine and Omeprazole on Total Acid Secretion and Gastric Ulcer Healing Effect in Albino Rats