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Vitiligo an acquired pigmentary disorder of the skin and mucous membranes characterized by well circumscribed, depigmented macules and patches resulting from selective destruction of melanocytes. CRP is an acute phase protein secreted by the liver in response to several inflammatory cytokines such as IL6. Since inflammatory and immune factors plays a key role in the pathogenesis of vitiligo, we aimed to assess the relationship between the serum level of hs-CRP and pathogenesis and severity of vitiligo. Material and methods: The study was conducted in the Dept. of Biochemistry and Dept. of Dermatology and Venereology in MGM Medical College & M Y Hospital Indore after approval from ethical committee on 70 Confirmed & diagnosed cases of Vitiligo patients of age group 18 to 55 years attending Dermatology OPD in MY Hospital Indore during a period of April 2018 to April 2019. Patients were divided into three groups according to the area of skin affected. Healthy individual without vitiligo were taken as controls. Venous blood sample was analyzed for serum hs-CRP levels and liver function. Appropriate statistical tests were applied on Minitab Version 17.0 and p values < 0.01was considered significant. Results: In our study the mean serum hs-CRP in case group was higher 12.09 ± 11.64 than in control group it was 1.99 ± 2.05 with negative but statistically significant correlation with age of onset of disease and positive statistically significant correlation with duration of disease thus, serum hs-CRP level might be useful for evaluating the disease activity of vitiligo as Novel biomarker. Conclusion: As high-sensitive C-reactive protein (hs-CRP) is an important sensitive diagnostic and prognostic marker in many systemic inflammatory diseases and very low concentrations of hs-CRP can be analyzed in the serum, its detection and serial measurements helps to provide a novel link to evaluate the disease activity and severity and response to treatment.

international journal of contemporary medical research

Assessment of Acute Phase Protein Serum hs-CRP Levels and its Role in Severity of Disease in Vitiligo Patients – A Hospital Based Case Control Study in M.Y. Hospital, Indore M.P.