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Prolotherapy is a minimally invasive technique used in the treatment of temporomandibular disorders. Prolotherapy agent induces an inflammatory process in the joint, stimulates fibroblast proliferation, hence facilitates the healing process and strengthens the joint and associated ligaments and tendons. The main aim of this article was to study the effect of 25% dextrose prolotherapy on temporomandibular joint pain, clicking and maximum mouth opening by using different injection sites. Material and methods: Sixty patients with established diagnosis of unilateral disc displacement with reduction who complained of unilateral symptoms (pain and clicking) were included in the study. They were randomly allocated to three groups (Group A, Group B and Group C) of 20 patients each. Group A patients received intra-articular injections into the superior joint space, Group B patients received injections into the inferior joint space where as Group C patients were given injections into the retrodiscal tissues. Each group received subsequent injections at first, second and third weeks at the respective sites. Pain, clicking and maximum mouth opening (MMO) was recorded pre-operatively, post-operatively at 3 weeks and 2 months. Results: Group B and Group C patients showed a significant decrease in the pain score at 3 weeks and 2 months postoperatively while as no significant pain relief was observed in Group A. Maximum mouth opening improved significantly in Group B and Group C patients at 3 weeks and 2 months and was highest in Group C. Reduction in clicking was best seen in Group C. Conclusion: Prolotherapy is more effective when injection site is selected as per the type of symptoms of the patients with temporomandibular disorders.

Evaluating the Effect of Dextrose Prolotherapy on Temporomandibular Disorders by Choosing Different Injection Sites- A Comparative Clinical Study