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Introduction: Osteoarthritis is a chronic degenerative condition of joint often associated with pain, deformity, disability in movement, and reduction in the quality of life. Study aimed to assess the utilization and efficacy of Plateletrich plasma (PRP), for the management of early knee osteoarthritis. Material and methods: Patients presenting with symptomatic early knee osteoarthritis were included in the study. They underwent infiltration of 5 ml PRP into the knee joint. Patients are evaluated 6 months after the procedure with Visual analogue scale (VAS) and range of motion assessment. Result: In our study of 150 patients with early osteoarthritis of knee, 58.6% presented with Kellgren lawrance grade 2 and remaining were grade 1 osteoarthritis. At 1 month follow up, the procedure gave excellent results in 32% patients and good results in 26% patients, better with Kellgren lawrance grade 1 osteoarthritis. At 3 month follow up, PRP infiltration gave excellent results in 47.3% patients with early osteoarthritis and good results in 37.3%. At 6 month follow up, results were excellent in 47.3% of patients and good results in 24.6% patients. Of the 71 patients showing excellent results, 57.7% had Kellgren Lawrance grade 1 osteoarthritis. Poor response following PRP infiltration is shown by only 2 patients Conclusion: Our study results support the application of autologous PRP as a safe and effective method in the treatment of the early stages of knee osteoarthritis. Significant clinical improvement was seen with 6 months of follow-up.

Functional Outcome of Early Knee Osteoarthritis Treated with Platelet Rich Plasma