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Laryngoscopy and tracheal intubation provokes a transient and marked sympathetic response that manifests as an increase in BP and HR, with the potential for development of arrhythmias. Study aimed to compare the efficacy of intravenous Dexmedetomidine and Esmolol in attenuating the cardiovascular stress responses accompanying laryngoscopy and endotracheal intubation in well-controlled hypertensive patients. Material and Methods: 60 hypertensive patients undergoing elective non cardiac surgery were included in the study. Patients were divided into 2 groups, Group D received Dexmedetomidine 1μg/kg and Group E received esmolol 1.5 mg/kg. HR, SAP, DAP, MAP were recorded. Results: There is statistical significant lower HR, SAP, DAP and MAP in group D compared to group E at T4 to T7. Intragroup analysis showed there is no statistically significant change of HR, SAP, DAP and MAP compared to baseline in Group D and returns to baseline at 10 minutes. Intragroup analysis showed there is statistically significant (Higher) change of HR, SAP, DAP and MAP compared to baseline in Group E at T5 to T8 and returns to baseline at 15 minutes. Conclusion: In controlled hypertensive patients, administration of dexmedetomidine infusion before induction of anaesthesia blunts the haemodynamic response to laryngoscopy and endotracheal intubation.

international journal of contemporary medical research

Comparative Evaluation of Dexmedetomidine and Esmolol for Attenuation of Intubation Stress Response in well Controlled Hypertensive Patients – A Double-Blind Randomized Control Study