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Recently in this laboratory 8-phenylthiacabamido-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4] benzodiazepine i.e.M-1, 8-(phenyl-2,4-dithiabiureto)-1-methyl-6-phenyl-4H-[1,2,4] triazolo[4,3-a][1,4] benzodiazepine i.e.M-2, 8-[(3-phenylimino)-1,2,4-dithiazolo]-amino-1-methyl-6-phenyl-4H-[1,2,4]triazolo [4,3-a][1,4] benzodiazepine i.e.M-3, 8-[(2-phenylimino-6-phenylamino)-1,3,5-dithiazinoimino]-1-methyl-6-phenyl-4H-[1,2,4] triazolo[4,3a][1,4]benzodiazepine i.e.M-4, 8-[(2-thio-3-phenyl-6-phenylamino)-1,3,5-thiadiazino]imino-1-methyl-6-phenyl-4H[1,2,4] triazolo [4,3-a] [1,4] benzodiazepine i.e.M-5 were synthesized and their antimicrobial activities were tested against E. coli, B. subtilis, S. typhi, S. aureus, B. megatherium, A. aerogenes, P. vulgaris by Disc diffusion method and MIC methods. These compounds showed good results.

Studies in the Antimicrobial Activities of Some Newly Synthesized [1,4] Substituted Benzodiazepines by Disc Diffusion Method and MIC Methods