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Giant cell lesions of bone include true giant cell tumors & numerous benign osteoclasts and pseudo-anaplastic-appearing giant cells containing variants.Many times it is difficult to differentiate between true giant cell tumor and other tumor like conditions. Aims: To study histopathology of various giant cell rich tumor and tumor like conditions of bone. Methods and Material:  Retrospective analysis of 50 cases of giant-cell rich lesions of bone diagnosed and treated at Smt. N.H.L. Municipal Medical College Ahmedabad, Gujarat during  1 st January 2002 to 1 st January 2003 included in the study. Patients’ clinical, radiological details, histopathological examination were studied using structured proforma. The cases were classified in different categories according to age groups, types of tumour, benign versus malignant category. Results: The most common giant cell containing benign tumor is giant cell tumor (19 cases) followed by Aneurysmal bone cyst (5), Most of the giant cell containing tumors of bone are found in younger age group and are located in epiphysis The common giant cell containing malignant tumor is  osteogenic sarcoma (7 cases) followed by Talangiectatic O.S  (01). The majority of cases found in age between 15 - 28 years and most common sites are epiphysis of long bones. Conclusion: The most common giant cell rich benign bone tumor is giant cell tumor and most common giant cell rich malignant bone tumor is osteosarcoma commonly occurs in younger age groups in the epiphysis region long bones DOI:10.21276/APALM.1524

A study of Giant Cell Lesions of Bone