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Hyperglycemic exposure, ex vivo of erythrocytes is often employed as a model for understanding membrane modifications in erythrocytes due to enhanced oxidative stress in diabetes. Chronic hyperglycemia leads to free radicals' generation along with an increase in insulin resistance. In the current study, the effect of Cinnamomum zeylanicum Blume, hydroacetone extract on oxidative stress and membranes of erythrocytes exposed to hyperglycemic conditions was investigated. Hemolysis as a measure of lipid peroxidation was studied by exposing erythrocytes to an increasing glucose concentration in presence and absence of the cinnamon extract. In erythrocytes subjected to lower glucose concentrations, the percent hemolysis was higher. Higher glucose concentration attenuated hemolysis. Cinnamon extract supplementation reduced hemolysis by 91.20-50.10% in presence of 10-100 mM glucose, respectively. The results also illustrated that cinnamon extract supplementation significantly reduced oxidative stress induced-damage and enhanced activity of superoxide dismutase, evaluated by inhibition of pyrogallol auto-oxidation. It can, thus be hypothesized that cinnamon can prevent lipid peroxidation and enzyme glycation in human erythrocytes under diabetic condition.

Ex vivo study of Cinnamomum zeylanicum Blume on antioxidative system and structural modifications of erythrocytes under hyperglycemic conditions