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By studying the influence factors of insider trading in the process of Mergers & Acquisitions (M&A)for 952 Chinese firms from 2001 to 2014 at the perspective of corporate governance, and puts forward relevant policy suggestions. The empirical results show that the reasonable arrangement of corporate governance structure can produce certain restrictions on insider trading; At the same time, the larger the M&A size is, the more severe insider trading. This conclusion means that, under the current background of China, in order to protect the interests of investors, it is necessary to continue to adjust the governance structure and perfect the governance of listed companies; For the larger M&A of listed companies, supervision departments should strengthen supervision andthe quality of information disclosure of listed companies to safeguard the rights and interests of investors.