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Background: Polycystic ovary syndrome (PCOS) is a most common endocrine /metabolic disorder of women in their reproductive ages. Although PCOS is complex, but there is strong evidence that candidate genes on insulin action have been proposed to show a vital role in its etiology. Aim:The current research was designed to study the effect of (rs2241766T>G)in adiponectin gene with PCOS, and their impact on the level of serum adiponectinand insulin resistance (HOMA-IR) in Iraqi women with PCOS. Methods: The case –control design study was performed on 120 women with and without PCOS. Phenotypic analysis included the estimation of fasting levels of; blood glucose, and lipid profile by spectrophotometric methods, while insulin, and adiponectin concentrations were determined by ELISA. Genotyping of the selected SNP(rs2241766T>G) in the adiponectin gene was carried out by (PCR-RFLP) technique. Results:After controlling for the age, body mass index, significant difference in Waist circumferences, fasting insulin, HOMA-IR, and serum adiponectin levels were found in POCS group with respects to those of a healthy control group.Genotyping and alleles results of the selected SNP (rs2241766T>G) were not associated with incident of PCOS. However, women with PCOS with TG and GG genotype had higher insulin levels, and HOMA-IR than carriers of the TTgenotype. Conclusions: The current study point out that the selected SNP (rs2241766T>G) in adiponectin gene is not relatedto PCOS in Iraqi women. Nevertheless, the selected polymorphism was found to be associated with insulin levels, and HOMA-IR among Iraqi women with PCOS, and to impact adiponectin secretion.Further research with a greater sample size, and more SNPs in adiponectin gene are wanting to confirm these results.

Effect of rs2241766T>G polymorphism in Adiponectin Gene on Circulating Adiponectin Levels among Iraqi Women with PCOS