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Aim: Present study was conducted to assess the efficacy of hyaluronidase in enhancing the effect of inferior alveolar nerve block when used in conjugation with lidocain. Methods: Patients diagnosed with irreversible pulpitis in mandibular molars were selected for study. After noting the baseline stimulus on premolars by electronic pulp tester, inferior alveolar nerve block was injected. Thirty minutes after the onset of anesthesia placebo and hyaluronidase was injected during the control and test phase of the study respectively. Duration of the anesthesia was recorded with the help of electronic pulp tester on the premolar and by needle prick on the gingiva. Results: Significant increase in the pulpal and gingival anesthesia was observed by administering hyaluronidase after the lidocain injection. Conclusion: Hyaluronidase when used before the end of anesthetic effect of lidocain in inferior alveolar nerve blocks can increase the efficacy of anesthetic.

Efficacy of Hyaluronidase in Enhancing the Effect of Inferior Alveolar Nerve Block when Used in Conjugation with Lidocain