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Purpose: Evaluation of red cell transfusion effects on tissue oxygenation, by measuring blood lactate levels before and after hemotransfusion. Blood lactate levels are suggested as sensitive parameter to evaluate tissue oxigenation. The aim of this study was to verify the efficiency of hemotransfusions that were performed on patients in intensive care based on lactate level. Study Design: Prospective observational. Methods: In this prospective observational study on (n59 patients) who considered that required red cell transfusion.(the patients more that 25 point according to APACHE II-score were excluded).We monitor vital signs (BP, HR) at admission and also was strictly observed lactate level and hemoglobin level at admission before red cell transfusion (pre T), two hours after transfusion (2h post T) and 24 hours after (24 h post T with or no any another red cell transfusion). At first the patients group based at hemoglobin level, Group Ia with Hb< 8g/dl and Group IIb with Hb ≥ 8g/dl. After that the patients group again based at lactate level, Group Ic lactat level ≥ 2, 4 and Group IId lactate level <2, 4. Results: Comparison between group Ia and group IIb as belongs hemoglobin level demonstrate significance only at admission pre T and lost significance at 2h post T and 24h post T, at the other hand differences between group Ic and gropIId as belongs hemoglobin level stay significant at pre T, 2h post T and 24h post T. Conclusions: Statistical significant evaluation (p < 0, 05) between above mentioned groups shown that lactate level are very sensitive indicator in measuration of tissue oxygenation..Another important finding was significant high mortality and morbidity at patient group with lactate level ≥ 2, 5.

Evaluation of Red Cell Transfusion Effects on Tissue Oxigenation, Based on Blood Lactate Levels As Sensitive Indicator of Tissue Oxygenation