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and purpose. This article is devoted to the actual problem of dentistry, namely, cytomorphometric changes in the gingival epithelium of patients with cardio-respiratory pathology. The purpose is to study the cytological and morphometric parameters of gingival epitheliocytes in patients with chronic obstructive pulmonary disease in combination with coronary heart disease. Materials and methods. 239 patients were examined: the main group, 130 patients with COPD in combination with chronic obstructive pulmonary disease with coronary heart disease; comparison group 1: 38 patients diagnosed with chronic obstructive pulmonary disease; and the comparison group 2: 71 patients with coronary heart disease. The control group is represented by 20 somatically healthy patients. Morphometric and cytological studies were performed on scrapings of gingival epithelium according to standard procedure with staining with azur-eosin and studying under light microscope. Results and discussion: It is noted that in patients with co-morbid pathology, the cells at in the late stages of differentiation are more common. Clear leukocyte infiltration is noted in the preparations, and morphometric analysis shows significant decrease in the nuclear-cytoplasmic ratio in patients of all groups due to an increase in the epithelial cell nucleus (p < 0.05), with no significant changes in the cell cytoplasm. Conclusions: This fact justifies the need for early diagnosis of possible violations in the oral cavity, as well as the development of an algorithm for their prevention and treatment.

CYTOMORPHOMETRIC CHANGES IN GINGIVAL EPITHELIOCYTES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PUIMONARY IN COMBINATION WITH CORONARY HEART DISEASE