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The electrochemical behavior of Pravastatin, a lipid-lowering drug, on a glassy carbon electrode was explored in Britton-Robinson buffer by using cyclic and square-wave voltammetry. Cyclic voltammetric studies indicated that the compound underwent irreversible oxidation, which was a diffusion-controlled process. Using square-wave voltammetry, Pravastatin could be determined at +1.24 V (vs. Ag/AgCl) in the concentration range 2.4×10-7-2.8×10-6 M at pH 2.0, with a detection limit of 5.0×10-8 M. The suggested method was successfully applied for the assay of Pravastatin in tablets.

Pravastatin′in Camımsı Karbon Elektrot üzerinde Kare-dalga Voltametrisi ile İlaç Formülasyonunda Tayini