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One of the main factors that differentiate people in terms of the effectiveness of therapeutic procedures or side effects is the variability in DNA repair capabilities. The aim of the study was to investigate the response of DNA damage repair systems in human lymphocytes irradiated with the therapeutic proton beam in the Bronowice Cyclotron Center of Institute of Nuclear Physics, Polish Academy of Sciences (IFJ PAN) in compare to X-rays. Lymphocytes from healthy donors were irradiated in the Spread-Out Bragg Peak of the proton beam or as reference X-rays. For both sources of radiation, the kinetics of the DNA damage repair capabilities were estimated using the comet assay method (0–120 min) and γ-H2AX test (0-24h). Preliminary results from the comet assay show a similar time and repair efficiency of induced DNA damage for both types of radiation. However, in a group involving X-rays, significant inter-individual differences were observed. With the γ-H2AX test, inter-individual differences in the repair capabilities were not noted. These findings indicate that induced DNA damage repair mechanisms after proton irradiation may be different when compared to X-rays.

DNA REPAIR PROCESSES IN HUMAN LYMPHOCYTES IRRADIATED WITH A 60-MeV PROTON RADIOTHERAPEUTIC BEAM