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Reactive oxygen species (ROS) play in the male reproductivesystem important physiological functions in cell signaling, spermatogenesisand sperm maturation in epididymis. The influenceof various factors, e.g. environmental, could be the reason foroxidative stress. This can lead to the exposure of cells to thetoxic effects of many oxidants such as O•⁻₂, O₃, H₂O₂, •OH. Thesource of ROS may be spermatozoa, which also, due to the compositionof the cytoplasmic membrane lipids and great amountof mitochondria are particularly susceptible to oxidative damage.Oxidative stress can damage their membranes, DNA, inhibitsperm motility and reduce their fertilization ability. This dualeffect of ROS confirms the unique role of antioxidant enzymes(such as SOD, CAT and GPX) and non-enzymatic (e.g. GSH, vitaminsA, E, C, transferrin) responsible for maintaining adequatelevels of ROS in the male reproductive system.

Ochrona przed stresem oksydacyjnym w męskim układzie płciowym