English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Crystal engineering is a focus area for constructing interesting H-bond zigzag channel-like network structures with some special tectons. In such a system, the host and guest components construct extended structures in the solid state through non-covalent interactions between the molecular subunits.1 Such studies are utilized in separation science and pharmacological profiles,2 and have received great attention in supramolecular chemistry. As per our interest to identify different kinds of potential building blocks that form zigzag channels and entrap organic guest molecules, we have found that sulfamethoxazole (SMZ, known for its antitumor or protease inhibitor activity3) forms H-bond zigzag channel and entraps 8-hydroxyquinoline (8-HQN, known for antibacterial, and carcinogenic activities4). Due to the important roles of both drugs in biological systems, we found it prudent to perform crystal structure studies on complexes of SMZ with 2-hydroxyquinoline (2-HQN), 4-hydroxyquinoline (4-HQN), and 8-HQN in order to understand the effects of the position(s) of N in the quinoline molecule on complex formation with SMZ, the molecular association of the SMZ molecules, and the H-bond network between interacting groups in SMZ and quinoline derivatives. Unfortunately, we obtained only the SMZ/8-HQN complex after several unsuccessful attempts, and herein report on its crystal structure regarding the aforementioned aims. The crystals were grown by dissolving SMZ and 8-HQN in a 1:1 stoichiometry ratio in methanol/ethanol mixed solvents, warmed, and left for slow evaporation to obtain crystals after five days and characterized through X-ray diffraction. Crystal intensity data were collected using graphite-monochromated X-ray Structure Analysis Online

x-ray structure analysis online

The Crystal Structure of Entrapped 8-Hydroxyquinoline Molecules in an Interleaved Hydrogen Bonded &lt;i&gt;Zigzag&lt;/i&gt; Channel of Sulfamethoxazole Molecules