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Multi-component reactions (MCRs) have been extensively investigated in organic and diversity oriented synthesis, primarily due to their ability to generate complex functionality from simple starting materials in a one-step transformations.1,2 Great efforts have been, and still are made to find and develop new multi-component reactions. An isocyanide-based multicomponent reaction has a magic situation for providing a diversity oriented synthesis. Here, we introduce the crystal structure product of a multi-component (3+1) reaction of isocyanide and alkylidene Meldrum’s acid.3–6 The title compound was prepared by the reaction of cyclohexyl isocyanide and alkylidene Meldrum’s acid (3:1 ratio) in dichloromethane at room temperature within four hours (Fig. 1). After evaporating the solvent, ethanol was added to the residue, and a white powder was separated from the reaction mixture. More purification and recrystallization was done in hot ethanol. The crystal structure (Fig. 2) was solved by direct methods and refined on F2 by full-matrix least-squares procedures. The title compound crystallized in triclinic space group P1 with cell parameters a = 6.6634(3)Å, b = 12.3296(6)Å, c = 17.0338(8)Å, a = 86.394(1) ̊, b = 81.052(1) ̊, g = 85.002(1) ̊, V = 1375.43(11)Å3, Z = 2, Dcal = 1.226 Mg/m3 at T = 100(2)K. The non-hydrogens were refined anisotropically, and all of the hydrogens were fixed as a riding model over their heavier atoms. A fine cycle refinement [I > 2s(I)] converged to R1 = 0.0480 and wR2 = 0.1143 for the observed reflections [I > 2s(I)] is 5663. Crystal data and other relevant parameters for the compound are given in Table 1. All atoms in the furo-pyran ring are in a plane; except for C6, all three cyclohexyl rings of isocyanides adapt to a chair conformation, and their plane aligns in a noncoplanar way with respect to the furo-pyran plane. The spiro cycloheptyl ring has a chair conformation. The bond lengths of the furopyran atoms are normal. Although the imine bond lengths of N(1)–C(2) and N(2)–C(5) are similar, the bond lengths of N(3)– C(6) show a slight elongation. As a result, these bond lengths X-ray Structure Analysis Online

Crystal Structure of 2,3,7-Tris(cyclohexylimino)-3,4-dihydro-4-spirocycloheptan-2H-furo[3,4-b]pyran-5(7H)-one