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平板上に作製された微小流路内においてキャピラリー電気泳動の原理に基づく分離分析を行うマイクロチップ電気泳動MCEは微量の試料を高速かつ高い分離能で分析することが可能であるしかしその反面低い濃度感度が汎用化のための大きな障壁となっているそこで濃度感度の向上を目的としてオンライン試料濃縮法のMCEへの適用が進められているその結果最大で百万倍程度の高感度化が達成されたがその反面分析時間の大幅な増加や分離能の低下を引き起こすことがあるこの欠点を改善するために著者らは分離溶液の部分的注入PF法をMCEに適用し分離能の向上及び分析時間の短縮を達成したまたPF法をオンライン試料濃縮法と組み合わせることによりトランジエントトラッピング法を開発したこれらの新規な方法論に基づくより高度なMCE分析について新たに得られた知見とともに紹介するMicrochip electrophoresis (MCE), which is based on capillary electrophoresis, is performed in a microchannel fabricated on a planner plate. MCE provides rapid and high-resolution analyses for a small amount of analytes. In MCE, however, a low concentration sensitivity is often problematic, which interferes further progress of MCE. To improve the sensitivity, several on-line sample preconcentration techniques have been applied to MCE. However, they sometimes cause a decrease in the separation efficiency and/or an increase in the analysis time. To overcome these problems, we applied a partial filling technique to MCE, and developed an on-line sample preconcentration technique, named "transient-trapping". These novel approaches should provide a high-performance MCE analysis

High-Performance Microchip Electrophoresis by Using On-Line Sample Preconcentration and Partial Filling Techniques