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Long-term stability is a key property of enzyme membranes that can be used for biosensors, bioreactors, and bio-fuel cells. This review discusses factors that decrease the stability, and provides two examples of enzyme membranes, a polyion complex membrane and a cellulose membrane, with which stability loss can be avoided. By using these materials, long-term stability was improved. These supporting materials could be applied to construct biosensors, bioreactors, and bio-fuel cells.

Supporting Materials That Improve the Stability of Enzyme Membranes