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A molecularly imprinted polymer-modified potentiometric histamine (HIS) sensor was prepared and used for quantitative determination of HIS in bovine serum. The calibration curve using the potential responses measured in 1 × 10 -3 mol L -1 phosphate buffer (pH 7.4) showed good linearity in the HIS concentration range of 3 × 10 -4 to 1 × 10 -2 mol L -1 (r = 0.92), with a detection limit of 1.6 × 10 -4 mol L -1 . In bovine serum samples, the HIS sensor showed good recovery values of 91 - 104%. Therefore, this HIS sensor successfully determined the HIS concentration in bovine serum samples.

Application of Molecularly Imprinted Polymer-modified Potentiometric Sensor for Quantitative Determination of Histamine in Serum