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Tuberkulosis paru masih merupakan masalah dunia. Indonesia menempati peringkat ke tiga di dunia pada tahun 2012. Target nasional Case Detection Rate tahun 2012 adalah 70%, sedangkan pencapaian Jawa Tengah sebesar 58,48%. Penelitian ini bertujuan untuk memperoleh batas kadar interferon (IFN) γ pada orang kontak serumah dengan penderita tuberkulosis paru sebagai dasar diagnosis dini penyakit tuberkulosis. Penelitian dilakukan secara kohort selama dua tahun (2011 - 2013) di Balai Kesehatan Masyarakat Paru Semarang. Pada akhir penelitian, terdapat 12 responden kontak dan 13 tidak kontak serumah. Uji Wilcoxon menunjukkan perbedaan bermakna rerata kadar IFN-γ antara kelompok kontak dengan kelompok tidak kontak serumah (nilai p = 0,004). Rerata kadar IFN-γ pada kontak serumah mengalami penurunan pada sebagian besar kasus (75%). Pada kelompok kontak serumah, 25% menunjukkan gejala klinis suspek tuberkulosis paru. Pemeriksaan mikrobiologis menunjukkan 100% negatif pada kedua kelompok. Hasil reciever operating characteristic kadar IFN-γ terhadap status klinis, diperoleh nilai area under the curve sebesar 70,4% (95% CI= 40,8% - 99,9%). Nilai cut off point IFN-γ yang optimal secara statistik yaitu pada nilai ≥3,277. Diperoleh hasil sensitivitas dan spesifisitas sebesar 67,7%. Pemeriksaan kadar IFN-γ dapat digunakan dalam kegiatan skrining untuk mendeteksi secara dini penularan pada kontak serumah dengan penderita tuberkulosis paru, sebagai pilot project pada daerah dengan prevalensi tuberkulosis paru yang tinggi. Tuberculosis remains a global problem. In 2012, Indonesia has the third biggest tuberculosis cases in the world. The national target in Case Detection Rate for tuberculosis in 2012 was 70%, whereas Jawa Tengah reached only 58.48%. This research aimed to find interferon (IFN) g level among households contact with tuberculosis patient that used a new screening method of finding tuberculosis cases. The research design was a two-year cohort study (2011 - 2013) took place in pulmonary community health centers Semarang. In the end of research, found 12 participants household contact and 13 participants nonhousehold contact. Wilcoxon test result showed significant differences IFN-g level between contact group and noncontact group (p value= 0.004). IFN-g among household contact group decreased in most cases (75%). Among household contact group showed 25% had a clinical symptom of tuberculosis. Microbiology diagnostic showed 100% had negative result in both group. Result of receiver operating characteristic IFN-g level toward clinical status, had value area under curve 70.4% (95% CI= 40.8%-99.9%). Cut off point of IFN-g value have optimal result in ³3.277, with sensitivity and specificity value 67.7%. IFN-g level test can be used in screening program to early detection of infected among household contact with new tuberculosis cases, as a pilot project in high prevalence of new tuberculosis cases.

Diagnosis Dini Tuberkulosis pada Kontak Serumah dengan Penderita Tuberkulosis Paru melalui Deteksi Kadar IFN-γ