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Conditional Reciprocal Best Hits (CRBH) was originally described by Aubry et al.(Aubry et al. 2014) and implemented in the crb-blast package. CRBH is a method for finding orthologs between two sets of sequences which builds on the traditional Reciprocal Best Hits (RBH) method; it improves RBH by finding an expect-value cutoff per alignment length, and then selecting non-reciprocal alignments which meet the minimum threshold.

shmlast: An improved implementation of Conditional Reciprocal Best Hits with LAST and Python