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The knowledge of the phenomena that affect the composition of milk can help improve these aspects. Nutritional genomics evaluates the synergism of important factors such as genetics and nutrition, and it has taken hold as a tool to explain the correct gear between these factors and can help improve productivity rates in dairy herds. The objective of this research was to explore the interaction between nutrient supply in the diet and the effect of polymorphisms of BGH, PRL and IGF2A genes on the percentage of protein and fat in Holstein cows from the department of Antioquia. For this purpose, we considered the phenotypic and genotypic information from 1070 Holstein cows distributed in 21 herds in the department of Antioquia. The animals were genotyped by RFLP PDR-technique. The contribution of dry matter, protein and energy diet was determined through visits, measurements and estimates made monthly in each herd. In models for milk fat and protein interactions, a significant effect (p<0.05) between the level of consumption of dry matter, crude protein and net energy of lactation and BGH gene polymorphisms, PRL and IGF2a was found. In the linear regression analysis, significant effects (p<0.05) were found in the total supply of nutrients, in the BGH gene for percentage of fat and protein in milk. Significant effects (p<0.05) were found for PRL gene in average total contribution of nutrients and fat percentage in milk, for IGF2a significant effects (p<0.05) in the total contribution of medium nutrients and fat percentage in milk protein were found, which shows that the effect of genotype is different depending on the nutritional status of the animals.

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Efecto de la interacción del nivel nutricional de la dieta y el polimorfismo de los genes BGH, PRL e IGF2a sobre el porcentaje de grasa y proteína en la leche de ganado Holstein