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Since 1979, all outpatient pharmacy transactions at the US Public Health Service Hospital in Seattle have been captured in a computer system which generates a profile of each patient's active and previously used drugs. We conducted a controlled trial in which patients were allocated to profile or no-profile groups while the computer continued to collect data on everyone. In all, 41,572 clinic visits made by 6,186 patients were studied. The incidence of preventable drug-drug interactions and redundancies was very low and was unaffected by profiles. For unclear reasons, prescription of two interacting drugs on the same visit was significantly more common for patients with profiles. The duration of drug-drug interaction episodes was significantly shorter for profile group patients, perhaps due to earlier detection of the error on subsequent visits. Profiles had no effect on prescribing volume or coordination of drug refill and visit schedules, but profile group patients made about 5 per cent fewer clinic visits than those in the no-profile group. In this setting, it appears that the prescribing of interacting or redundant drugs is more often due to inadequate provider knowledge than to inaccessible patient-specific drug data. Prevention of such errors would thus require a more active educational or monitoring program.

The Seattle evaluation of computerized drug profiles: effects on prescribing practices and resource use.