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C-X-C chemokine receptor type 4 ( CXCR4 ) has a certain effect on renal fibrosis, and there are few specific studies in cells. We want to investigate the impact of suppressing CXCR4 activity on the expression of renal fibrosis-related genes in primary glomerular endothelial cells, mesangial cells, and podocytes.

Suppressing the activity of CXCR4 down-regulates the expression of renal fibrosis related genes in primary glomerular cells