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Malignant melanoma, which originates from melanocytes located in the skin or mucous membranes, is an invasive cancer with a high fatality rate (1). The incidence of malignant melanoma has increased steadily in recent years, giving it one of the highest mortality rates among human cancers (1,2). Age and family history, exposure to ultraviolet radiation, fair skin, and dysplastic nevi syndrome are the known risk factors for malignant melanoma progression (3), and the typical characteristics of melanoma are early metastasis and uncontrolled growth (4). Surgery, radiation therapy, and chemotherapy, the current therapeutic interventions for metastatic melanoma, are insufficient to achieve durable responses (5). Therefore, combinations of treatment modalities, including immunotherapies and molecularly targeted therapies, must be explored for the treatment of advanced melanoma (6,7). Although some treatments have shown clinical benefit, understanding the mechanism of melanoma progression will reveal additional targets (8). Hence, identifying new biomarkers and exploring the mechanisms involved in melanoma progression are critical for the development of novel melanoma therapies. Nucleolar complex protein 14 (NOP14) is a nucleolar stress response protein responsible for 18S rRNA maturation and 40S ribosome production (9). Because ribosomes play Original Article

EMG1 interacts with NOP14 to regulate the growth, migration, and invasion of melanoma cells via the Wnt/β-catenin pathway