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Esophageal cancer is the seventh most malignant tumors; with high mortality, it also ranks sixth in cancer-related deaths worldwide (1). The two major histological types are esophageal adenocarcinoma (EC) and esophageal squamous cell carcinoma (ESCC). The former frequently occurs in western countries, while the latter is more predominant in Asian countries, particularly China, accounting for more than 90% of the total cases (2). Despite advances in therapy such as surgery, radiation therapy, chemotherapy, and Original Article

translational cancer research

High programmed death-ligand 1 expression is a poor prognostic indicator for esophageal squamous cell carcinoma and is correlated with two-field lymph node metastasis