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Colorectal cancer (CRC) is the third most common cancer and fourth leading cause of cancer death worldwide. The incidence of CRC has been rapidly rising in many Asian countries in the past few decades (1). Approximately 21% of CRC are diagnosed with the existence of metastasis, and these patients have a 5-year survival rate of 13.8% in the United States in 2018 (2). However, there is a limited improvement in the 5-year survival during the past several decades (2). During tumorigenesis, the normal epithelium of the gastrointestinal tract becomes hyperproliferative mucosa, and then becomes carcinoma which is associated with sequential activation of specific oncogenes and/or Original Article

Interaction between linc01615 and miR-491-5p regulates the survival and metastasis of colorectal cancer cells