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Department of Chemotherapy, Chinese Academy of Sciences University Cancer Hospital (Zhejiang Cancer Hospital), Hangzhou, China; Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing, China; Department of Medical Oncology, Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Department of Oncology, Sir Run Run Shaw Hospital, Hangzhou, China; Department of Lung Cancer, the Fifth Medical Center, General of PLA, Beijing, China; Department of Medical Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China; Department of Oncology, the Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, China; Department of Oncology, Baotou Cancer Hospital, Baotou, China; Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China Contributions: (I) Conception and design: L Lei, WX Wang; (II) Administrative support: MY Fang, CW Xu; (III) Provision of study materials or patients: YC Zhu, XX Pu, Y Fang, W Zhuang, YB Zhang, LP Wang; (IV) Collection and assembly of data: L Lei, WX Wang; (V) Data analysis and interpretation: MY Fang, CW Xu; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. These authors contributed equally to this work. Correspondence to: Chun-Wei Xu, MD, PhD. Department of Pathology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, No. 420, Fuma Road, Fuzhou, China. Email: xuchunweibbb@163.com; Mei-Yu Fang, MD, PhD. Department of Chemotherapy, Zhejiang Cancer Hospital, No. 1 Banshan East Street, Gongshu District, Hangzhou, China. Email: fangjade2004@icloud.com.

translational cancer research

Association between BRAF mutant classification and the efficacy of pemetrexed-based chemotherapy in Chinese advanced non- small cell lung cancer patients: a multicenter retrospective study