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Breast cancer is the most common cancer (excluding skin cancers) and is the second leading cause of cancer death among women (1,2). Axillary lymph node status is important for the staging of breast cancer to evaluate the recurrence, metastasis and prognosis (3,4). According to the current tumor-node-metastasis (TNM) staging system for breast cancer of American Joint Committee on Cancer (AJCC) and other committees, 6–10 axillary lymph nodes at least should be collected from the breast cancer specimens for accurate histologic examination and proper tumor stage (5,6). The N stage is evaluated by the number of positive lymph node (PLN); however, each patient is heterogeneous and the prognosis of the patient is limited and inaccurate by only evaluating the node-stage. Therefore, the concept of negative lymph node (NLN) count has been proposed Original Article

Negative lymph node count is an independent prognostic factor for female patients with node positive breast cancer