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Semen analysis (SA) is the cornerstone for male infertility evaluation. Variations in sperm quantity and quality may make SA an unreliable decision-making tool in providing an insight of infertility (1). Consequently, efforts have been made to upgrade techniques of male fertility analysis. In recent times, primary investigative techniques have centered around assessing sperm capacity, sperm function, sperm morphology and sperm nucleus. Advances in the field of male infertility research have brought about strategies for assessing sperm chromatin quality and DNA fragmentation (2).

Should sperm DNA fragmentation testing be routinely used in assessing male infertility?