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For patients with previously diagnosed dual primary tumors, it is usually difficult to determine the diagnosis and treatment of stage IV recurrence. The study was to explore the influences of 18 F-fluoroestradiol positron emission tomography/computed tomography ( 18 F-FES PET/CT) in the diagnosis of estrogen receptor (ER) positive breast cancer combined with other primary tumor with distant metastases.

The clinical value of 18F-fluoroestradiol in assisting individualized treatment decision in dual primary malignancies