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Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity. Indeed, Roquin dysfunction has been linked to autoimmunity in mice. Essig and colleagues (2017) determine their functions in Foxp3 + T regulatory cells and uncover novel mechanisms of Roquin-mediated regulation of its target mRNAs (1).

How T cells go rogue in the absence of Roquins