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Metals are incinerated along with plant extracts and used as oral drugs in the Indian traditional medicines, such as Ayurveda and Siddha. Gold and silver ashes are predominantly used in cancer therapy and for treating neuronal disorders. Since the beginning of the nano-era, these ashes were investigated for their characteristics, especially the size of the particles. Numerous hypotheses were advanced to repurpose them as nanomedicines. During the last two decades, several studies were conducted studying the correlation of the particle size and the therapeutic effects. Here, we discuss the processes used to prepare gold and silver ash that result in the formation of nanoand micro-scale particles. Further, we review recent works on the ashes using modern tools and their scope, in nanomedicine. We emphasize the need to generate experimental data of high-quality to reinforce the scientific validation of these traditional medicines.

A Narrative review of scientific validation of gold- and silver-based Indian medicines and their future scope