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Central sleep apnea (CSA) is common in heart failure (HF) patients. Traditional treatment of CSA, including continuous positive airway pressure (CPAP), adaptive servo ventilation (ASV), oxygen therapy, and CO 2 inhalation, has respective limitations. Transvenous phrenic nerve stimulation (PNS), a novel therapeutic approach for CSA, was proved to be effective and safe. The remedē ® system and related transvenous PNS methods was approved by FDA in 2017, for treating moderate to severe CSA.

Transvenous phrenic nerve stimulation, a novel therapeutic approach for central sleep apnea