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Noise-induced hearing loss (NIHL) is one of the most common form of severe sensorineural hearing impairment (1). At present, more than 10 million employees work in environments with excessive noise levels in China and millions of them experience varying degrees of hearing impairment (2). Both environmental and genetic factors contribute to the occurrence and severity of NIHL (3). Our previous studies illustrated that Notch, SIK3, KCNE1, and ATP2B2 genes were associated with NIHL in Chinese workers (4-8). The BCL-2 gene encodes an integral outer mitochondrial Original Article

Functional BCL-2 rs2279115 Noncoding variant associated with noise-induced hearing loss in Chinese workers: a case-control study