Open AccessExpression and prognostic significance of thrombospondin gene family in gastric cancer
Author(s) -
Longying Deng,
Xiangfu Zeng,
Dan Tang,
Wei Deng,
Hongfu Liu,
Yuankang Xie
Publication year - 2021
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo-21-54
Subject(s) - medicine , cancer , thrombospondin 1 , gene , thrombospondin , cancer research , oncology , bioinformatics , genetics , angiogenesis , metalloproteinase , matrix metalloproteinase , biology
Thrombospondins (THBSs) are glycoproteins expressed in the extracellular matrix (ECM) and have critical roles in tumor development and metastasis. However, the diverse expression patterns and prognostic roles of distinct THBS genes in gastric cancer have not been fully elucidated. In the current study, we aimed to investigate the expression patterns of THBSs in gastric cancer (GC) and determine whether they are prognostic markers for this malignancy.
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