Open AccessBioinformatical identification of key genes regulated by IGF2BP2- mediated RNA N6-methyladenosine and prediction of prognosis in hepatocellular carcinoma
Author(s) -
Qiang Wei
Publication year - 2021
Publication title -
journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.084
H-Index - 39
eISSN - 2219-679X
pISSN - 2078-6891
DOI - 10.21037/jgo-21-306
Subject(s) - gene knockdown , gene , biology , n6 methyladenosine , microarray analysis techniques , microarray , cancer research , messenger rna , gene expression , hepatocellular carcinoma , rna , genetics , methyltransferase , methylation
The treatment of hepatocellular carcinoma (HCC), a malignant cancer with global spread, remains unsatisfactory, and novel prognostic biomarkers need to be identified. N6-methyladenosine (m 6 A) has been found to regulate tumor initiation and progression through different mechanisms. As a dynamic and reversible messenger RNA (mRNA) modification, m 6 A can be read by insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2). IGF2BP2 targets thousands of mRNA transcripts, which may be involved in HCC progression.
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