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The recent Southampton consensus guideline and two previous international consensus meetings held in Louisville and Morioka in 2008 and 2014, respectively have recommended laparoscopic liver resection (LLR) as a standard procedure for selected patients with colorectal liver metastases (CRLM) (1-3). The Oslo-CoMet and LapOpHuva studies are the only two randomized controlled trials (RCTs) that have provided solid evidence showing that LLR is a safer, less invasive, and more cost- effective approach with higher health-related quality of life and oncological outcomes equivalent to those of open liver resection (OLR) for patients with CRLM (4-6). Many cohort studies that used propensity score matching (PSM) and their meta-analyses have demonstrated decreased intraoperative blood loss, blood transfusion rate, and morbidity; shorter hospital stays; and improved postoperative quality of life in LLR patient groups than in OLR groups (7-9). Additionally, long-term outcomes have been found to be comparable between these two treatment groups.

Does laparoscopic liver resection for colorectal liver metastases provide a true survival benefit compared with open liver resection?