Open AccessAntidepressant functions of Jie Yu Chu Fan capsule in promoting hippocampal nerve cell neurogenesis in a mouse model of chronic unpredictable mild stress
Author(s) -
Meng Ji,
Shiqin Niu,
Heyin Mi,
Peng Jang,
Yue Li,
Wenli Hu
Publication year - 2020
Publication title -
annals of translational medicine
Language(s) - English
Resource type - Journals
eISSN - 2305-5847
pISSN - 2305-5839
DOI - 10.21037/atm-20-5599
Subject(s) - behavioural despair test , homovanillic acid , tail suspension test , open field , neurogenesis , fluoxetine , neurotrophic factors , endocrinology , brain derived neurotrophic factor , chronic stress , hippocampal formation , medicine , hippocampus , imipramine , pharmacology , dopamine , antidepressant , biology , neuroscience , serotonin , receptor , pathology , alternative medicine
Our study demonstrated that JYCF exhibits antidepressant activity comparable to that of fluoxetine in CUMS mice. Moreover, the antidepressant-like activity of JYCF was shown to be mediated by enhancing hippocampal nerve cell neurogenesis through increasing the levels of monoamine neurotransmitters and BDNF expression.
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