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Department of Internal Medicine, Inha University Hospital and School of Medicine, Incheon, South Korea Correspondence to: Jin-Woo Lee, MD, PhD. Professor of Medicine, Division Chief of Gastroenterology and Hepatology, Inha University Hospital, 27 Inhang-Ro, Jung-Gu, Incheon 22332, South Korea. Email: jin@inha.ac.kr. Provenance and Peer Review: This article was commissioned by the editorial office, Annals of Translational Medicine. The article did not undergo external peer review. Comment on: Zhao S, Dou W, Fan Q, et al. Identifying optimal candidates of transarterial chemoembolization (TACE) vs. sorafenib in patients with unresectable hepatocellular carcinoma. Ann Transl Med 2020;8:587.

Limitations of the Barcelona clinic liver cancer staging treatment strategy in hepatocellular carcinoma patients with performance status 1